Runs of Homozygosity Do Not Influence Survival to Old Age

被引：9
|
作者：
Kuningas, Maris [1 ]
McQuillan, Ruth [2 ]
Wilson, James F. [2 ]
Hofman, Albert [1 ,3 ]
van Duijn, Cornelia M. [1 ,3 ]
Uitterlinden, Andre G. [1 ,3 ,4 ]
Tiemeier, Henning [1 ,3 ,5 ]
机构：
[1] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
[2] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland
[3] Netherlands Consortium Healthy Aging, Netherlands Genom Initiat, Leiden, Netherlands
[4] Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands
[5] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands
来源：
PLOS ONE | 2011年 / 6卷 / 07期
关键词：
EXTENDED TRACTS; POPULATIONS; IDENTIFY;
D O I：
10.1371/journal.pone.0022580
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.
引用
收藏
页数：3
相关论文
共 50 条
  • [41] The use of runs of homozygosity for estimation of recent inbreeding in Holstein cattle
    Gurgul, A.
    Szmatola, T.
    Topolski, P.
    Jasielczuk, I.
    Zukowski, K.
    Bugno-Poniewierska, M.
    [J]. JOURNAL OF APPLIED GENETICS, 2016, 57 (04) : 527 - 530
  • [42] Analysis of runs of homozygosity of cattle living in different climate zones
    Falchi, Laura
    Cesarani, Alberto
    Mastrangelo, Salvatore
    Senczuk, Gabriele
    Portolano, Baldassare
    Pilla, Fabio
    Macciotta, Nicolo P. P.
    [J]. JOURNAL OF ANIMAL SCIENCE, 2023, 101
  • [43] The distribution of runs of homozygosity in nine native Russian sheep breeds
    Deniskova, Tatiana Evgenievna
    Abdelmanova, Alexandra
    Dotsev, Arsen V.
    Reyer, Henry
    Selionova, Marina I.
    Fornara, Margaret S.
    Wimmers, Klaus
    Brem, Gottfried
    Zinovieva, Natalia A.
    [J]. JOURNAL OF ANIMAL SCIENCE, 2020, 98 : 456 - 456
  • [44] Characterizing Runs of Homozygosity and Their Impact on Risk for Psychosis in a Population Isolate
    Melhem, Nadine M.
    Lu, Cong
    Dresbold, Cara
    Middleton, Frank A.
    Klei, Lambertus
    Wood, Shawn
    Faraone, Stephen V.
    Vinogradov, Sophia
    Tiobech, Josepha
    Yano, Victor
    Roeder, Kathryn
    Byerley, William
    Myles-Worsley, Marina
    Devlin, Bernie
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2014, 165 (06) : 521 - 530
  • [45] Detection of runs of homozygosity in conserved and commercial pig breeds in Poland
    Szmatola, Tomasz
    Jasielczuk, Igor
    Semik-Gurgul, Ewelina
    Szyndler-Nedza, Magdalena
    Blicharski, Tadeusz
    Szulc, Karolina
    Skrzypczak, Ewa
    Gurgul, Artur
    [J]. JOURNAL OF ANIMAL BREEDING AND GENETICS, 2020, 137 (06) : 571 - 580
  • [46] Joint Estimates of Heterozygosity and Runs of Homozygosity for Modern and Ancient Samples
    Renaud, Gabriel
    Hanghoj, Kristian
    Korneliussen, Thorfinn Sand
    Willerslev, Eske
    Orlando, Ludovic
    [J]. GENETICS, 2019, 212 (03) : 587 - 614
  • [47] Characteristics of runs of homozygosity in selected cattle breeds maintained in Poland
    Szmatola, Tomasz
    Gurgul, Artur
    Ropka-Molik, Katarzyna
    Jasielczuk, Igor
    Zabek, Tomasz
    Bugno-Poniewierska, Monika
    [J]. LIVESTOCK SCIENCE, 2016, 188 : 72 - 80
  • [48] The use of runs of homozygosity for estimation of recent inbreeding in Holstein cattle
    A. Gurgul
    T. Szmatoła
    P. Topolski
    I. Jasielczuk
    K. Żukowski
    M. Bugno-Poniewierska
    [J]. Journal of Applied Genetics, 2016, 57 : 527 - 530
  • [49] Inbreeding coefficients and runs of homozygosity islands in Brazilian water buffalo
    Nascimento, A., V
    Cardoso, D. F.
    Santos, D. J. A.
    Romero, A. R. S.
    Scalez, D. C. B.
    Borquis, R. R. A.
    Neto, F. R. A.
    Gondro, C.
    Tonhati, H.
    [J]. JOURNAL OF DAIRY SCIENCE, 2021, 104 (02) : 1917 - 1927
  • [50] Effect of Artificial Selection on Runs of Homozygosity in US Holstein Cattle
    Kim, Eui-Soo
    Cole, John B.
    Huson, Heather
    Wiggans, George R.
    Van Tassell, Curtis P.
    Crooker, Brian A.
    Liu, George
    Da, Yang
    Sonstegard, Tad S.
    [J]. PLOS ONE, 2013, 8 (11):
12345