An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro

被引：153
|
作者：
Larsen, E
Kharazmi, A
Christensen, LP
Christensen, SB
机构：
[1] Res Ctr Aarslev, Danish Inst Agr Sci, Dept Food Sci, DK-5792 Aarslev, Denmark
[2] Copenhagen Univ Hosp, Rigshosp, Dept Clin Microbiol, DK-2200 Copenhagen, Denmark
[3] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 07期
关键词：
D O I：
10.1021/np0300636
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-beta-D-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa caning by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in rose hips may explain the clinically observed antiinflammatory properties of rose hip herbal remedies.
引用
收藏
页码：994 / 995
页数：2
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