An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro

被引：153
|
作者：
Larsen, E
Kharazmi, A
Christensen, LP
Christensen, SB
机构：
[1] Res Ctr Aarslev, Danish Inst Agr Sci, Dept Food Sci, DK-5792 Aarslev, Denmark
[2] Copenhagen Univ Hosp, Rigshosp, Dept Clin Microbiol, DK-2200 Copenhagen, Denmark
[3] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 07期
关键词：
D O I：
10.1021/np0300636
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-beta-D-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa caning by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in rose hips may explain the clinically observed antiinflammatory properties of rose hip herbal remedies.
引用
收藏
页码：994 / 995
页数：2
相关论文
共 50 条
  • [1] Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo
    Kharazmi A.
    Winther K.
    InflammoPharmacology, 1999, 7 (4) : 377 - 386
  • [2] Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations
    Wenzig, E. M.
    Widowitz, U.
    Kunert, O.
    Chrubasik, S.
    Bucar, F.
    Knauder, E.
    Bauer, R.
    PHYTOMEDICINE, 2008, 15 (10) : 826 - 835
  • [3] Rose hip (Rosa canina L.) oil obtained from waste hip seeds by different extraction methods
    Szentmihályi, K
    Vinkler, P
    Lakatos, B
    Illés, V
    Then, M
    BIORESOURCE TECHNOLOGY, 2002, 82 (02) : 195 - 201
  • [4] Isolation and structure elucidation of pectic polysaccharide from rose hip fruits (Rosa canina L.)
    Ognyanov, Manol
    Remoroza, Connie
    Schols, Henk A.
    Georgiev, Yordan
    Kratchanova, Maria
    Kratchanov, Christo
    CARBOHYDRATE POLYMERS, 2016, 151 : 803 - 811
  • [5] Isolation of Immunomodulatory Triterpene Acids from a Standardized Rose Hip Powder (Rosa canina L.)
    Saaby, Lasse
    Jager, Anna Katharina
    Moesby, Lise
    Hansen, Erik Wind
    Christensen, Soren Brogger
    PHYTOTHERAPY RESEARCH, 2011, 25 (02) : 195 - 201
  • [6] Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro
    Baseras, Billur
    Gaida, Matthias M.
    Kahle, Nadine
    Schuppel, Ann-Kathrin
    Kathrey, Diana
    Prior, Birgit
    Wente, Moritz
    Haensch, Gertrud Maria
    IMMUNOBIOLOGY, 2012, 217 (01) : 83 - 90
  • [7] Characterization of anti-inflammatory triterpene acids from rose hip powder (Rosa canina L.)
    Saaby, L.
    Jager, A.
    Moesby, L.
    Hansen, E.
    Christensen, S.
    PLANTA MEDICA, 2010, 76 (12) : 1171 - 1172
  • [8] Indomethacin induces chemotaxis of human peripheral blood eosinophils in vitro
    Heinemann, A
    Stubbs, VEL
    Schartl, P
    Peskar, BA
    Sabroe, I
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2002, 365 : R77 - R77
  • [9] Genetic diversity among native wild hip rose (Rosa canina L.) genotypes collected from Kashmir valley
    Verma, M. K.
    Lal, S.
    Ahmed, N.
    Kumar, Dinesh
    Singh, D. B.
    Sagoo, P. A.
    INDIAN JOURNAL OF HORTICULTURE, 2015, 72 (02) : 250 - 256
  • [10] Inhibitory Effect of Quercetin Isolated from Rose Hip (Rosa canina L.) against Melanogenesis by Mouse Melanoma Cells
    Fujii, Takashi
    Saito, Morio
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2009, 73 (09) : 1989 - 1993
12345