Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia

被引：5

作者：

Kustanovich, AM ^{[1
]}

Savitskaja, TV ^{[1
]}

Bydanov, OI ^{[1
]}

Belevtsev, MV ^{[1
]}

Potapnev, MP ^{[1
]}

机构：

[1] Belarussian Res Ctr Pediat Oncol & hematol, Mol Biol Lab, Minsk 223040, BELARUS

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 11期

关键词：

tumor suppressor genes; chimeric oncogenes; acute lymphoblastic leukemia; pediatric; RT-PCR;

D O I：

10.1016/j.leukres.2005.04.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aberrant expression of tumor suppressor genes WT1, RB1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML1, MLL-AF4, E2A-PBX1, SIL-TAL1 were determined in bone marrow samples of children with de novo B-lineage (n = 170) and T-lineage (n = 25) acute lymphoblastic leukemia (ALL). In contrast to expression of chimeric oncogenes alterations in p16, WT1, RB1 and p53 expression were T/B-lineage-unrestricted. Significant association between expression of MLL-AF4 and WT1, E2A-PBX1 and p53; SIL-TAL1 and homozygous deletion of p16 has been demonstrated. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1271 / 1276

页数：6

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