Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia

被引：5
|
作者：
Kustanovich, AM [1 ]
Savitskaja, TV [1 ]
Bydanov, OI [1 ]
Belevtsev, MV [1 ]
Potapnev, MP [1 ]
机构：
[1] Belarussian Res Ctr Pediat Oncol & hematol, Mol Biol Lab, Minsk 223040, BELARUS
来源：
LEUKEMIA RESEARCH | 2005年 / 29卷 / 11期
关键词：
tumor suppressor genes; chimeric oncogenes; acute lymphoblastic leukemia; pediatric; RT-PCR;
D O I：
10.1016/j.leukres.2005.04.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aberrant expression of tumor suppressor genes WT1, RB1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML1, MLL-AF4, E2A-PBX1, SIL-TAL1 were determined in bone marrow samples of children with de novo B-lineage (n = 170) and T-lineage (n = 25) acute lymphoblastic leukemia (ALL). In contrast to expression of chimeric oncogenes alterations in p16, WT1, RB1 and p53 expression were T/B-lineage-unrestricted. Significant association between expression of MLL-AF4 and WT1, E2A-PBX1 and p53; SIL-TAL1 and homozygous deletion of p16 has been demonstrated. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1271 / 1276
页数：6
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