Influence of Lightweight Ambulatory Oxygen on Oxygen Use and Activity Patterns of COPD Patients Receiving Long-Term Oxygen Therapy

被引:42
|
作者
Casaburi, Richard [1 ]
Porszasz, Janos [1 ]
Hecht, Ariel [1 ]
Tiep, Brian [2 ]
Albert, Richard K. [3 ,4 ]
Anthonisen, Nicholas R. [5 ]
Bailey, William C. [6 ]
Connett, John E. [7 ]
Cooper, J. Allen, Jr. [6 ,8 ]
Criner, Gerard J. [9 ]
Curtis, Jeffrey [10 ]
Dransfield, Mark [6 ,8 ]
Lazarus, Stephen C. [11 ,12 ]
Make, Barry [13 ]
Martinez, Fernando J. [10 ]
McEvoy, Charlene [14 ]
Niewoehner, Dennis E. [15 ]
Reilly, John J. [16 ]
Scanlon, Paul [17 ]
Scharf, Steven M. [18 ]
Sciurba, Frank C. [19 ]
Woodruff, Prescott [11 ,12 ]
机构
[1] Univ Calif Los Angeles, Los Angeles Biomed Res Inst, Med Ctr, Rehabil Clin Trials Ctr, Torrance, CA 90502 USA
[2] City Hope Natl Med Ctr, Duarte, CA 91010 USA
[3] Denver Hlth, Dept Med, Denver, CO USA
[4] Univ Colorado, Hlth Sci Ctr, Aurora, CO USA
[5] Univ Manitoba, Winnipeg, MB, Canada
[6] Univ Alabama Birmingham, Div Pulm Allergy & Crit Care Med, Birmingham, AL USA
[7] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA
[8] Birmingham VAMC, Pulm Sect, Birmingham, AL USA
[9] Temple Univ, Div Pulm & Crit Care Med, Philadelphia, PA 19122 USA
[10] Univ Michigan, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
[11] Univ Calif San Francisco, Div Pulm & Crit Care Med, San Francisco, CA 94143 USA
[12] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[13] Natl Jewish Hlth, Denver, CO USA
[14] HealthPartners Res Fdn, Minneapolis, MN USA
[15] Univ Minnesota, VA Med Ctr, Pulm Sect, Minneapolis, MN USA
[16] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA USA
[17] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA
[18] Univ Maryland, Div Pulm & Crit Care Med, Baltimore, MD 21201 USA
[19] Univ Pittsburgh, Div Pulm & Crit Care Med, Pittsburgh, PA USA
关键词
adherence; long-term oxygen therapy; activity monitoring; tri-axial accelerometer; OBSTRUCTIVE PULMONARY-DISEASE; RANDOMIZED-TRIAL; STANDARDIZATION; HOME; PRESCRIPTION; SURVIVAL;
D O I
10.3109/15412555.2011.630048
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Lightweight ambulatory oxygen devices are provided on the assumptions that they enhance compliance and increase activity, but data to support these assumptions are lacking. We studied 22 patients with severe chronic obstructive pulmonary disease receiving long-term oxygen therapy (14 men, average age = 66.9 y, FEV1 = 33.6% pred, PaO2 at rest = 51.7 torr) who were using E-cylinders as their portable oxygen. Subjects were recruited at 5 sites and studied over a 2-week baseline period and for 6 months after randomizing them to either continuing to use 22-lb E-cylinders towed on a cart or to carrying 3.6-lb aluminum cylinders. Utilizing novel electronic devices, ambulatory and stationary oxygen use was monitored continuously over the 2 weeks prior to and the 6 months following randomization. Subjects wore tri-axial accelerometers to monitor physical activity during waking hours for 2-3 weeks prior to, and at 3 and 6 months after, randomization. Seventeen subjects completed the study. At baseline, subjects used 17.2 hours of stationary and 2.5 hours of ambulatory oxygen daily. At 6 months, ambulatory oxygen use was 1.4 +/- 1.0 hrs in those randomized to E-cylinders and 1.9 +/- 2.4 hrs in those using lightweight oxygen (P = NS). Activity monitoring revealed low activity levels prior to randomization and no significant increase over time in either group. In this group of severe chronic obstructive pulmonary disease patients, providing lightweight ambulatory oxygen did not increase either oxygen use or activity. Future efforts might focus on strategies to encourage oxygen use and enhance activity in this patient group. This trial is registered at ClinicalTrials.gov (NCT003257540).
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页码:3 / 11
页数:9
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