High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis

被引：0
|
作者：
Cui, Xiao-Xiao [1 ,2 ]
Zhou, Chen [3 ]
Lu, Huan [2 ]
Han, Yan-Li [1 ]
Wang, Feng-Mian [2 ]
Fan, Wei-Rong [2 ]
Ren, Yuan [1 ,2 ]
Zhang, Rong [1 ,2 ]
机构：
[1] Anhui Univ Sci & Technol, Huainan, Peoples R China
[2] Hlth Sci Affiliated Sixth Peoples Hosp, Dept Obstet & Gynecol, South Campus, Shanghai, Peoples R China
[3] Changzhou 2 Peoples Hosp, Dept Gynecol, Changzhou, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2020年 / 13卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Ovarian cancer; transcription factor ZNF93; small interfering siRNA; cell proliferation; cell migration; STATISTICS; APOPTOSIS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer (OC) is most common type of gynecologic cancer and is frequently lethal. It is important to determine the pathologic mechanisms underlying OC. ZNF93 is a member of the zinc finger protein family. Abnormal expression of ZNF93 has been observed in various tumor cells. However, its clinical significance and biologic function in ovarian cancer remain unclear. In the present study, we established that ZNF93 expression was highly up-regulated in OC samples and was closely correlated with clinical stage, indicating poor prognosis. We then established that ZNF93 promoted OC cell proliferation and migration. The results of our study may provide insight into the use of ZNF93 as a marker of clinical outcome and as a potential therapeutic target in OC.
引用
收藏
页码：944 / 953
页数：10
相关论文
共 50 条
  • [41] High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion
    Kim, Ha-Jeong
    Jeon, Hye-Kyung
    Cho, Young Jae
    Park, Young Ae
    Choi, Jung-Joo
    Do, In-Gu
    Song, Sang Young
    Lee, Yoo-Young
    Choi, Chel Hun
    Kim, Tae-Joong
    Bae, Duk-Soo
    Lee, Jeong-Won
    Kim, Byoung-Gie
    EUROPEAN JOURNAL OF CANCER, 2012, 48 (12) : 1914 - 1921
  • [42] High Galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion
    Lee, Jeong-Won
    Kim, Ha-Jeong
    Jeon, Hye-Kyung
    Cho, Young Jae
    Park, Young Ae
    Choi, Jung-Joo
    Lee, Yoo-Young
    Choi, Chel Hun
    Kim, Tae-Joong
    Bae, Duk-Soo
    Kim, Byoung-Gie
    CANCER RESEARCH, 2012, 72
  • [43] High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration
    Diao, Nannan
    Li, Yuzheng
    Yang, Jinling
    Jin, Chengjuan
    Meng, Xiaohui
    Jiao, Wenlin
    Feng, Jinbo
    Liu, Zhenping
    Lu, Nan
    BIOMEDICINE & PHARMACOTHERAPY, 2019, 115
  • [44] High expression of TRIM24 predicts worse prognosis and promotes proliferation and metastasis of epithelial ovarian cancer
    Zhang, Liwei
    Chen, Hong
    Ding, Baijuan
    Jiang, Wei
    JOURNAL OF OVARIAN RESEARCH, 2022, 15 (01)
  • [45] High expression of TRIM24 predicts worse prognosis and promotes proliferation and metastasis of epithelial ovarian cancer
    Liwei Zhang
    Hong Chen
    Baijuan Ding
    Wei Jiang
    Journal of Ovarian Research, 15
  • [46] RAB10 promotes breast cancer proliferation migration and invasion predicting a poor prognosis for breast cancer
    Zhuo, Jian
    Han, Jianjun
    Zhao, Yanchun
    Hao, Ruiying
    Shen, Chong
    Li, He
    Dai, Luxian
    Sheng, Ankang
    Yao, Hanyu
    Yang, Xiaohong
    Liu, Weiguang
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [47] RAB10 promotes breast cancer proliferation migration and invasion predicting a poor prognosis for breast cancer
    Jian Zhuo
    Jianjun Han
    Yanchun Zhao
    Ruiying Hao
    Chong shen
    He Li
    Luxian Dai
    Ankang Sheng
    Hanyu Yao
    Xiaohong Yang
    Weiguang Liu
    Scientific Reports, 13
  • [48] Ubiquitin-specific protease 1 overexpression indicates poor prognosis and promotes proliferation, migration, and invasion of gastric cancer cells
    Meng, Debin
    Li, Delong
    TISSUE & CELL, 2022, 74
  • [49] ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways
    Zhang, Jingjing
    Wu, Xiaoli
    Huang, Li
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2022, 52 (04): : 611 - 620
  • [50] Eukaryotic elongation factors 2 promotes tumor cell proliferation and correlates with poor prognosis in ovarian cancer
    Shi, Nannan
    Ghen, Xiaojing
    Liu, Rong
    Wang, Danping
    Su, Min
    Wang, Qiang
    He, Aiqin
    Gu, Hongmei
    TISSUE & CELL, 2018, 53 : 53 - 60
12345