Facile synthesis of 4-and 7-azaindoles from the corresponding imines by palladium-catalyzed cascade C-C and C-N coupling

被引：21
|
作者：
Ngo Nghia Pham [1 ,2 ]
Thanh Tuan Dang [1 ]
Ngoc Thang Ngo [1 ,3 ]
Villinger, Alexander [1 ]
Ehlers, Peter [1 ]
Langer, Peter [1 ,3 ]
机构：
[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany
[2] VNU Univ Sci Hanoi VNU HUS, Fac Chem, Hanoi, Vietnam
[3] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 21期
关键词：
ONE-POT SYNTHESIS; PHASE SYNTHESIS; ARYL IMINES; AZAINDOLE; DESIGN; 7-AZATRYPTOPHAN; HYDROGENATION; OPTIMIZATION; INHIBITORS; 4-AZAINDOLES;
D O I：
10.1039/c5ob00720h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cyclization of 2,3-dihalopyridines with readily available imines provides a convenient and regioselective approach to 4- and 7-azaindoles. The regioselectivity can be controlled by the choice of the halogen atoms at the pyridine ring (chlorine versus bromine).
引用
收藏
页码：6047 / 6058
页数：12
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