Facile synthesis of 4-and 7-azaindoles from the corresponding imines by palladium-catalyzed cascade C-C and C-N coupling

被引：21

作者：

Ngo Nghia Pham ^{[1
,2
]}

Thanh Tuan Dang ^{[1
]}

Ngoc Thang Ngo ^{[1
,3
]}

Villinger, Alexander ^{[1
]}

Ehlers, Peter ^{[1
]}

Langer, Peter ^{[1
,3
]}

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] VNU Univ Sci Hanoi VNU HUS, Fac Chem, Hanoi, Vietnam

[3] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 21期

关键词：

ONE-POT SYNTHESIS; PHASE SYNTHESIS; ARYL IMINES; AZAINDOLE; DESIGN; 7-AZATRYPTOPHAN; HYDROGENATION; OPTIMIZATION; INHIBITORS; 4-AZAINDOLES;

D O I：

10.1039/c5ob00720h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclization of 2,3-dihalopyridines with readily available imines provides a convenient and regioselective approach to 4- and 7-azaindoles. The regioselectivity can be controlled by the choice of the halogen atoms at the pyridine ring (chlorine versus bromine).

引用

页码：6047 / 6058

页数：12

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