Prognostic significance of E-cadherin, β-catenin and cyclin D1 in oral squamous cell carcinoma: a tissue microarray study

Objective. To study the prognostic significance of E-cadherin, beta-catenin, and cyclin D1 expression in oral squamous cell carcinoma. Subjects and Methods. The study included 65 subjects with histologically confirmed squamous cell carcinoma. TMA blocks were prepared for immunohistochemical quantification of the expression of the three markers using IHC profiler and Immune ratio plugin of Image J. Results. E-cadherin expression was significantly correlated with histological grades and the metastasis status (p<0.05), whereas beta-catenin expression was significantly correlated with smoking and tumor significantly correlated with depth of invasion and tumor death by 2.5 times (OR=2.53 and 0.84 respectively). Conclusion. High expression of beta-catenin and cyclin having tumor recurrence and cancer related death.