Preparation of Optically Pure Tertiary Phosphine Oxides via the Addition of P-Stereogenic Secondary Phosphine Oxide to Activated Alkenes

被引：32

作者：

Wang, Ji-Ping ^{[1
]}

Nie, Shao-Zhen ^{[1
]}

Zhou, Zhong-Yang ^{[1
]}

Ye, Jing-Jing ^{[1
]}

Wen, Jing-Hong ^{[1
]}

Zhao, Chang-Qiu ^{[1
]}

机构：

[1] Liaocheng Univ, Coll Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 17期

关键词：

CATALYZED ASYMMETRIC ALKYLATION; N-PHOSPHONYL IMINES; ENANTIOSELECTIVE SYNTHESIS; PEPTIDE-SYNTHESIS; BORANES; LIGANDS; HYDROPHOSPHINATION; STEREOCHEMISTRY; CHROMATOGRAPHY; SUBSTITUTION;

D O I：

10.1021/acs.joc.6b01371

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized P,C-stereogenic tertiary phosphine oxides were prepared by the addition of (R-P)-menthyl phenylphosphine oxide to activated olefins, in high dr(P) and dr(C), and were isolated in excellent yields. The reaction was readily catalyzed by Ca(OH)(2) or occurred with gentle heating. A wide range of substrates, including vinyl ketones, esters, nitriles, and nitro alkenes, can be used in the reaction.

引用

页码：7644 / 7653

页数：10

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