Adenosine kinase gene expression in human colorectal cancer

被引：33

作者：

Giglioni, S. ^{[1
]}

Leoncini, R. ^{[1
]}

Aceto, E. ^{[2
]}

Chessa, A. ^{[2
]}

Civitelli, S. ^{[2
]}

Bernini, A. ^{[2
]}

Tanzini, G. ^{[3
]}

Carraro, F. ^{[3
]}

Pucci, A. ^{[1
]}

Vannoni, D. ^{[1
]}

机构：

[1] Univ Siena, Dept Internal Med, Siena, Italy

[2] Univ Siena, Dipartimento Chirurg, I-53100 Siena, Italy

[3] Univ Siena, Dept Fisiol, I-53100 Siena, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2008年 / 27卷 / 6-7期

关键词：

adenosine kinase; qRT-PCR; purine metabolism; colorectal cancer;

D O I：

10.1080/15257770802145629

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate gene expression of adenosine kinase, a key enzyme in adenosine metabolism, in human intestinal biopsy specimens of 10 colorectal cancer patients. Quantitative mRNA expression levels were normalized against the reference gene -actin. The results showed that adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples.

引用

页码：750 / 754

页数：5

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