The prognostic value of CDX2 in colorectal cancer: a meta- analysis

Caudal-type homeodomain transcription factors 2 (CDX2) acts as an intestine-specific transcription factor is essential for intestinal differentiation and development, which shows a low expression in colorectal cancer tissues. However, the prognostic role of CDX2 in colorectal cancer remains controversial. Here, a meta-analysis of eight published studies containing 2547 patients was conducted to evaluate the prognostic value of CDX2 in colorectal cancer by calculating the hazard ratio (HR) and its 95% confidence interval (CI). The summary results revealed that the low expression of CDX2 was association with poor prognosis of OS (HR=1.99, 95% CI: 1.31-3.02) and DFS (HR=1.81, 95% CI: 1.08-3.05). Subgroup analysis showed decreased CDX2 was a significant prognostic marker in Asian patients (HR= 2.66, 95% CI: 1.38-5.13), but not in Caucasian (HR= 1.56, 95% CI: 0.94-2.59). This meta-analysis demonstrated that CDX2 could act as a significant biomarker in the prognosis of colorectal cancer.