Combined protective effects of anti-PhtD and anti-pneumococcal polysaccharides

被引：13
|
作者：
Denoel, Philippe [1 ]
Godfroid, Fabrice [1 ]
Hermand, Philippe [1 ]
Verlant, Vincent [1 ]
Poolman, Jan [1 ]
机构：
[1] GlaxoSmithKline Biol, Res & Dev, B-1330 Rixensart, Belgium
来源：
VACCINE | 2011年 / 29卷 / 38期
关键词：
Antibody; PhtD; Streptococcus pneumoniae; Serotype; 1; 3; ACUTE OTITIS-MEDIA; CONJUGATE VACCINE; DOUBLE-BLIND; PROTEIN-D; EFFICACY; CHILDREN; EMPYEMA; TRIAL; IMMUNOGENICITY; PNEUMONIA;
D O I：
10.1016/j.vaccine.2011.01.085
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the past years, a significant rise in the proportion of childhood complicated pneumonia cases related to pneumococcal serotypes 1 and 3 has been observed. PhtD is a vaccine candidate protein antigen. By using a pneumococcal lethal intranasal challenge mouse model, a significant additive effect on protection was observed with the combination of vaccination-induced anti-PhtD and injected anti-polysaccharide antibodies specific for serotypes 1 and 3. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6451 / 6453
页数：3
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