Development of Domino Reactions with β-Enamino Esters as Key Intermediates

被引：35
|
作者：
Han, Ying [1 ]
Sun, Ling [1 ]
Sun, Yan [1 ]
Gao, Hong [1 ]
Yan, Chaoguo [1 ]
机构：
[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 09期
基金：
中国国家自然科学基金;
关键词：
domino reaction; multicomponent reaction; electron-deficient alkyne; enamino ester; heterocycles; spirocycles; ONE-POT SYNTHESIS; AROMATIC-ALDEHYDES; DIALKYL ACETYLENEDICARBOXYLATES; POLYSUBSTITUTED PYRROLES; MULTICOMPONENT SYNTHESIS; 3-COMPONENT REACTIONS; 4-COMPONENT REACTIONS; METHYL PROPIOLATE; EFFICIENT; ARYLAMINES;
D O I：
10.6023/cjoc201206008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Domino reactions have attracted much high attention in recent years due to its convergence, productivity, facile execution and generation of highly diverse and complex products from easily available starting materials M a single operation. Addition of primary amines to electron-deficient alkynes could generated reactive enaminone (ester) in mild conditions, which have shown versatile reactivity and have been widely used in domino procedure as key reactive intermediate to develop a number of carbon-carbon bond formation reactions, heterocyclic and Spiro cyclic constructions. In this paper the recent developments of the domino reactions with enamino esters as key intermediates based on our experimental investigation are reviewed.
引用
收藏
页码：1577 / 1586
页数：10
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