Development of Domino Reactions with β-Enamino Esters as Key Intermediates

Domino reactions have attracted much high attention in recent years due to its convergence, productivity, facile execution and generation of highly diverse and complex products from easily available starting materials M a single operation. Addition of primary amines to electron-deficient alkynes could generated reactive enaminone (ester) in mild conditions, which have shown versatile reactivity and have been widely used in domino procedure as key reactive intermediate to develop a number of carbon-carbon bond formation reactions, heterocyclic and Spiro cyclic constructions. In this paper the recent developments of the domino reactions with enamino esters as key intermediates based on our experimental investigation are reviewed.