Development of indazole Rho-kinase (ROCK 1) inhibitors as potential antihypertensive agents

被引：0

作者：

Goodman, Krista Beaver ^{[1
]}

Dowdell, Sarah E. ^{[1
]}

Gaitanopoulos, Dimitri E. ^{[1
]}

Ivy, Robert ^{[1
]}

Sehon, Clark ^{[1
]}

Stavenger, Robert ^{[1
]}

Wang, Gren ^{[1
]}

Viet, Andrew Q. ^{[1
]}

Xu, Weiwei ^{[1
]}

Ye, Guosen ^{[1
]}

Semus, Simon F. ^{[2
]}

Evans, Christopher

Fries, Harvey E. ^{[3
]}

Jolivette, Larry J. ^{[3
]}

Jung, David K. ^{[1
]}

Wright, Lois L. ^{[4
]}

Smith, Gary K. ^{[4
]}

Behm, David J. ^{[5
]}

Bentley, Ross ^{[5
]}

Doe, Christopher P. ^{[5
]}

Hu, Erding ^{[5
]}

Lee, Dennis ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Dept Med Chem, King Of Prussia, PA 19406 USA

[2] GlaxoSmithKline Inc, Dept Computat & Struct Sci, King Of Prussia, PA 19422 USA

[3] GlaxoSmithKline Inc, Dept Drug Metab & Pharmacokinet, King Of Prussia, PA 19406 USA

[4] GlaxoSmithKline Inc, Screening & Compound Profiling, King Of Prussia, PA 19406 USA

[5] GlaxoSmithKline Inc, Cardiovasc & Urogenital CEDD, Biol, King Of Prussia, PA 19406 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 238卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

252-MEDI

引用

页数：1

共 50 条

[41] Rho-kinase inhibitors offer a new approach in the treatment of glaucoma
Challa, Pratap
Arnold, John J.
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2014, 23 (01) : 81 - 95
[42] Rho-Kinase Inhibitors for the Treatment of Refractory Diabetic Macular Oedema
Mateos-Olivares, Milagros
Garcia-Onrubia, Luis
Valentin-Bravo, Fco. Javier
Gonzalez-Sarmiento, Rogelio
Lopez-Galvez, Maribel
Pastor, J. Carlos
Usategui-Martin, Ricardo
Pastor-Idoate, Salvador
CELLS, 2021, 10 (07)
[43] Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors
Yhiya Amen
Qinchang Zhu
Hai-Bang Tran
Mohamed S. Afifi
Ahmed F. Halim
Ahmed Ashour
Kuniyoshi Shimizu
Journal of Natural Medicines, 2017, 71 : 380 - 388
[44] Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors
Amen, Yhiya
Zhu, Qinchang
Tran, Hai-Bang
Afifi, Mohamed S.
Halim, Ahmed F.
Ashour, Ahmed
Shimizu, Kuniyoshi
JOURNAL OF NATURAL MEDICINES, 2017, 71 (02) : 380 - 388
[45] The ups and downs of Rho-kinase and penile erection: upstream regulators and downstream substrates of rho-kinase and their potential role in the erectile response
K Chitaley
R C Webb
T M Mills
International Journal of Impotence Research, 2003, 15 : 105 - 109
[46] RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility
Domokos, Dora
Ducza, Eszter
Gaspar, Robert
EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 843 : 27 - 33
[47] Kinetic mechanism for human Rho-Kinase II (ROCK-II)
Trauger, JW
Lin, FF
Turner, MS
Stephens, J
LoGrasso, PV
BIOCHEMISTRY, 2002, 41 (28) : 8948 - 8953
[48] Effects of Rho-kinase inhibition on kidney development.
Meyer, TN
Schwesinger, C
Bush, KT
Stuart, RO
Steer, D
Nigam, SK
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 : 98A - 98A
[49] The ups and downs of Rho-kinase and penile erection: upstream regulators and downstream substrates of rho-kinase and their potential role in the erectile response
Chitaley, K
Webb, RC
Mills, TM
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2003, 15 (02) : 105 - 109
[50] Association of Rho-kinase 1 (ROCK1) Gene Polymorphisms with Behçet’s Disease
Elif Oguz
Abdullah Tuncay Demiryürek
Yavuz Pehlivan
Bünyamin Kisacik
Esma Ozkara
Serdar Oztuzcu
Belgin Alasehirli
Ahmet Mesut Onat
Molecular Diagnosis & Therapy, 2014, 18 : 419 - 426

← 1 2 3 4 5 →