Development of indazole Rho-kinase (ROCK 1) inhibitors as potential antihypertensive agents

被引:0
|
作者
Goodman, Krista Beaver [1 ]
Dowdell, Sarah E. [1 ]
Gaitanopoulos, Dimitri E. [1 ]
Ivy, Robert [1 ]
Sehon, Clark [1 ]
Stavenger, Robert [1 ]
Wang, Gren [1 ]
Viet, Andrew Q. [1 ]
Xu, Weiwei [1 ]
Ye, Guosen [1 ]
Semus, Simon F. [2 ]
Evans, Christopher
Fries, Harvey E. [3 ]
Jolivette, Larry J. [3 ]
Jung, David K. [1 ]
Wright, Lois L. [4 ]
Smith, Gary K. [4 ]
Behm, David J. [5 ]
Bentley, Ross [5 ]
Doe, Christopher P. [5 ]
Hu, Erding [5 ]
Lee, Dennis [1 ]
机构
[1] GlaxoSmithKline Inc, Dept Med Chem, King Of Prussia, PA 19406 USA
[2] GlaxoSmithKline Inc, Dept Computat & Struct Sci, King Of Prussia, PA 19422 USA
[3] GlaxoSmithKline Inc, Dept Drug Metab & Pharmacokinet, King Of Prussia, PA 19406 USA
[4] GlaxoSmithKline Inc, Screening & Compound Profiling, King Of Prussia, PA 19406 USA
[5] GlaxoSmithKline Inc, Cardiovasc & Urogenital CEDD, Biol, King Of Prussia, PA 19406 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
252-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors
    Goodman, Krista B.
    Cui, Haifeng
    Dowdell, Sarah E.
    Gaitanopoulos, Dimitri E.
    Ivy, Robert L.
    Sehon, Clark A.
    Stavenger, Robert A.
    Wang, Gren Z.
    Viet, Andrew Q.
    Xu, Weiwei
    Ye, Guosen
    Semus, Simon F.
    Evans, Christopher
    Fries, Harvey E.
    Jolivette, Larry J.
    Kirkpatrick, Robert B.
    Dul, Edward
    Khandekar, Sanjay S.
    Yi, Tracey
    Jung, David K.
    Wright, Lois L.
    Smith, Gary K.
    Behm, David J.
    Bentley, Ross
    Doe, Christopher P.
    Hu, Erding
    Lee, Dennis
    JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (01) : 6 - 9
  • [2] Therapeutic potential of Rho-kinase inhibitors in asthma
    Xing, Xi-Qian
    Gan, Ye
    Wu, Shang-Jie
    Chen, Ping
    Zhou, Rui
    Xiang, Xu-Dong
    MEDICAL HYPOTHESES, 2007, 68 (03) : 705 - 706
  • [3] Development of Rho-kinase inhibitors for cardiovascular medicine
    Shimokawa, Hiroaki
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 37P - 37P
  • [4] Translational research for the development of Rho-kinase inhibitors
    Shimokawa, Hiroaki
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103 : 18P - 18P
  • [5] Development of Rho-kinase inhibitors for cardiovascular medicine
    Shimokawa, Hiroaki
    Rashid, Mamunur
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2007, 28 (06) : 296 - 302
  • [6] Rho-kinase ROCK inhibitors reduce oligomeric tau protein
    Hamano, Tadanori
    Shirafuji, Norimichi
    Yen, Shu-Hui
    Yoshida, Hirotaka
    Kanaan, Nicholas M.
    Hayashi, Kouji
    Ikawa, Masamichi
    Yamamura, Osamu
    Fujita, Youshi
    Kuriyama, Masaru
    Nakamoto, Yasunari
    NEUROBIOLOGY OF AGING, 2020, 89 : 41 - 54
  • [7] Therapeutic potential of Rho-kinase inhibitors in cardiovascular diseases
    Hirooka Y.
    Shimokawa H.
    American Journal of Cardiovascular Drugs, 2005, 5 (1) : 31 - 39
  • [8] Development of specific Rho-kinase inhibitors and their clinical application
    Tamura, M
    Nakao, H
    Yoshizaki, H
    Shiratsuchi, M
    Shigyo, H
    Yamada, H
    Ozawa, T
    Totsuka, J
    Hidaka, H
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2005, 1754 (1-2): : 245 - 252
  • [9] Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases
    Yamaguchi, Muneo
    Nakao, Shintaro
    Arima, Mitsuru
    Wada, Iori
    Kaizu, Yoshihiro
    Hao, Feng
    Yoshida, Shigeo
    Sonoda, Koh-hei
    JOURNAL OF OPHTHALMOLOGY, 2017, 2017
  • [10] Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential
    Feng, Yangbo
    LoGrasso, Philip V.
    Defert, Olivier
    Li, Rongshi
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (06) : 2269 - 2300