Anti-inflammatory activity of Syzygium cumini bark

被引：89
|
作者：
Muruganandan, S [1 ]
Srinivasan, K [1 ]
Chandra, S [1 ]
Tandan, SK [1 ]
Lal, J [1 ]
Raviprakash, V [1 ]
机构：
[1] Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India
来源：
FITOTERAPIA | 2001年 / 72卷 / 04期
关键词：
Syzygium cumini; anti-inflammatory activity;
D O I：
10.1016/S0367-326X(00)00325-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The ethanolic extract of the bark of Syzygium cumini was investigated for its anti-inflammatory activity in animal models. The extract did not show any sign of toxicity up to a dose of 10.125 g/kg, p.o. in mice. Significant anti-inflammatory activity was observed in carrageenin (acute), kaolin-carrageenin (subacute), formaldehyde (subacute)-induced paw oedema and cotton pellet granuloma (chronic) tests in rats. The extract did not induce any gastric lesion in both acute and chronic ulcerogenic tests in rats. Thus, the present study demonstrated that S. cumini bark extract has a potent anti-inflammatory action against different phases of inflammation without any side effect on gastric mucosa. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：369 / 375
页数：7
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