Synthesis of [2H6]ceftazidime as a stable isotopically labeled internal standard

被引：0

作者：

Bian, Lei ^{[1
]}

Bushby, Nick ^{[2
]}

机构：

[1] Pharmaron Beijing Co Ltd, Beijing 100176, Peoples R China

[2] AstraZeneca UK Ltd, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2015年 / 58卷 / 07期

关键词：

ceftazidime; stable isotope; cephalosporin; ANTIBACTERIAL ACTIVITY; ACID-DERIVATIVES; CEFTAZIDIME; CEPHALOSPORINS;

D O I：

10.1002/jlcr.3290

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Ceftazidime is a third generation cephalosporin antibiotic that has activity against a wide range of Gram-negative and Gram-positive bacterial pathogens, including Escherichia coli and Pseudomonas aeruginosa. Stable isotope-labeled ceftazidime was required for use as an internal standard in LC-MS/MS assays, and a route was developed to make [H-2(6)]ceftazidime in eight steps from the commercially available labeled starting material [H-2(7)]isobutyric acid.

引用

页码：313 / 316

页数：4

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