Recent advances and approaches in the metal-free synthesis of 1,3-oxazole derivatives

This review presents an overview of recent advances and approaches in the metal-free synthesis of substituted 1,3-oxazole derivatives, which will enable organic researchers to identify the challenges in synthesizing these five-membered heterocyclic compounds. Specifically, 1,3-oxazole moiety containing compounds have been reported to possess a wide variety of applications, including in the medicinal, pharmaceutical, agrochemical and material sciences sectors. We classified these nonmetal-catalyzed synthetic approaches on the basis of their starting material's functionality that was used to synthesize 1,3-oxazole. This review covers the last six-year (2016-2021) of nonmetal catalyzed/mediated synthetic approaches.