1,3-oxazole derived cytisines

被引：0
|
作者：
E. R. Abdurakhmanova
S. G. Pil’o
K. M. Kondratyuk
A. V. Golovchenko
V. S. Brovarets
机构：
[1] National Academy of Sciences of Ukraine,Institute of Bioorganic Chemistry and Petrochemistry
来源：
Russian Journal of General Chemistry | 2017年 / 87卷
关键词：
cytisine; dichloroacrylonitrile; diethyl 1-acylamino-2,2,2-trichloroethylphosphonate; triphenylphosphonium salt; heterocyclization; 1,3-oxazole;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Reactions of 1-acylamino-2,2-dichloroacrylonitriles, diethyl 1-acylamino-2,2,2-trichloroethyl-phosphonates and 1-acylamino-2,2-dichloroethenylphosphonium salts with natural alkaloid cytisine have been studied. A series of novel multifunctional cytisine derivatives containing pharmacophore 1,3-oxazole moiety have been obtained. Composition and structure of the synthesized compounds have been confirmed by mass spectrometry and NMR spectroscopy data.
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页码：244 / 251
页数：7
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