Yangonindimers A-C, three new kavalactone dimers from Piper methysticum (kava)

被引：4

作者：

Song, Jia-Ling ^{[1
,2
]}

Li, Bai-Lin ^{[1
,2
]}

Yuan, Yao ^{[1
,2
]}

Nie, Ling-Hui ^{[3
]}

Niu, Jia ^{[1
,2
]}

Chiu, David ^{[4
]}

Xu, Zhi-Fang ^{[1
]}

Wu, Jie-Wei ^{[1
]}

Qiu, Sheng-Xiang ^{[1
]}

机构：

[1] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Program Nat Prod Chem Biol, Guangzhou, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China

[3] Southern Med Univ, Coll Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China

[4] High Sch Jr Davis Senior High Sch, Davis, CA USA

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 21期

基金：

中国博士后科学基金;

关键词：

Kavalactone dimers; yangonindimers A-C; Piper methysticum; cytotoxic activities; ANXIETY DISORDERS; HEPATOTOXICITY; CONSTITUENTS; EFFICACY; EXTRACTS; LACTONES;

D O I：

10.1080/14786419.2017.1312395

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new kavalactone dimers, designated as yangonindimers A-C (1-3), along with one known analogue were isolated from the roots of Piper methysticum. Their structures were elucidated via extensive analysis of their 1D, 2D NMR and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units. Compounds 1-4 were evaluated for their cytotoxic activities against human tumour cell lines NCI-H46, SW480 and HepG2, but none showed significant activity. [GRAPHICS] .

引用

页码：2459 / 2466

页数：8

共 50 条

[21] 3D Imaging and metabolomic profiling reveal higher neuroactive kavalactone contents in lateral roots and crown root peels of Piper methysticum (kava)
Jaiswal, Yogini S.
Yerke, Aaron M.
Bagley, M. Caleb
Ekelof, Mans
Weber, Daniel
Haddad, Daniel
Fodor, Anthony
Muddiman, David C.
Williams, Leonard L.
GIGASCIENCE, 2020, 9 (09):
[22] In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum)
Jhoo, JW
Freeman, JP
Heinze, TM
Moody, JD
Schnackenberg, LK
Beger, RD
Dragull, K
Tang, CS
Ang, CYW
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (08) : 3157 - 3162
[23] Structural characterization of genuine (-)-pipermethystine, (-)-epoxypipermethystine, (+)-dihydromethysticin and yangonin from the kava plant (Piper methysticum)
Naumov, Pance
Dragull, Klaus
Yoshioka, Masahiro
Tang, Chung-Shih
Ng, Seik Weng
NATURAL PRODUCT COMMUNICATIONS, 2008, 3 (08) : 1333 - 1336
[24] Kavalactones from Kava (Piper methysticum) root extract as modulators of recombinant human glycine receptors
Hegazy, Nada Hany
Breitinger, Hans-Georg
Breitinger, Ulrike
BIOLOGICAL CHEMISTRY, 2019, 400 (09) : 1205 - 1215
[25] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF KAVA LACTONES FROM PIPER-METHYSTICUM
SMITH, RM
THAKRAR, H
AROWOLO, TA
SHAFI, AA
JOURNAL OF CHROMATOGRAPHY, 1984, 283 (JAN): : 303 - 308
[26] Piperlongosides A-C, Three New Phenolic Constituents From Piper longum L.
Huyen, Le Thi
Hau, Nguyen Thi Thu
Kiem, Phan Van
NATURAL PRODUCT COMMUNICATIONS, 2023, 18 (01)
[27] Standard method performance requirements (SMPRS®) 2018.005: Determination of kavalactones and/or flavokavains from kava (Piper methysticum)
1600, AOAC International (101):
[28] Quantitative elimination of Flavokavines A and B from Kava Kava (Piper methysticum G. Forst) by isoelectric focused adsorptive bubble separation
Marlène Backleh
Perihan Ekici
Günther Leupold
Harun Parlar
Naturwissenschaften, 2003, 90 : 366 - 369
[29] Effects of Kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes
Zou, L
Henderson, GL
Harkey, MR
Sakai, Y
Li, A
PHYTOMEDICINE, 2004, 11 (04) : 285 - 294
[30] Quantitative elimination of Flavokavines A and B from Kava Kava (Piper methysticum G. Forst) by isoelectric focused adsorptive bubble separation
Backleh, M
Ekici, P
Leupold, G
Parlar, H
NATURWISSENSCHAFTEN, 2003, 90 (08) : 366 - 369

← 1 2 3 4 5 →