Yangonindimers A-C, three new kavalactone dimers from Piper methysticum (kava)

被引：4

作者：

Song, Jia-Ling ^{[1
,2
]}

Li, Bai-Lin ^{[1
,2
]}

Yuan, Yao ^{[1
,2
]}

Nie, Ling-Hui ^{[3
]}

Niu, Jia ^{[1
,2
]}

Chiu, David ^{[4
]}

Xu, Zhi-Fang ^{[1
]}

Wu, Jie-Wei ^{[1
]}

Qiu, Sheng-Xiang ^{[1
]}

机构：

[1] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Program Nat Prod Chem Biol, Guangzhou, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China

[3] Southern Med Univ, Coll Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China

[4] High Sch Jr Davis Senior High Sch, Davis, CA USA

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 21期

基金：

中国博士后科学基金;

关键词：

Kavalactone dimers; yangonindimers A-C; Piper methysticum; cytotoxic activities; ANXIETY DISORDERS; HEPATOTOXICITY; CONSTITUENTS; EFFICACY; EXTRACTS; LACTONES;

D O I：

10.1080/14786419.2017.1312395

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new kavalactone dimers, designated as yangonindimers A-C (1-3), along with one known analogue were isolated from the roots of Piper methysticum. Their structures were elucidated via extensive analysis of their 1D, 2D NMR and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units. Compounds 1-4 were evaluated for their cytotoxic activities against human tumour cell lines NCI-H46, SW480 and HepG2, but none showed significant activity. [GRAPHICS] .

引用

页码：2459 / 2466

页数：8

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