Basic approaches, challenges and opportunities for the discovery of small molecule anti-tumor drugs

被引：0

作者：

Ma, Yu-Shui ^{[1
,2
,3
]}

Liu, Ji-Bin ^{[2
]}

Yang, Xiao-Li ^{[3
]}

Xin, Rui ^{[3
]}

Shi, Yi ^{[1
,2
]}

Zhang, Dan-Dan ^{[3
]}

Wang, Hui-Min ^{[3
]}

Wang, Pei-Yao ^{[3
]}

Lin, Qin-Lu ^{[1
]}

Li, Wen ^{[1
]}

Fu, Da ^{[1
,3
]}

机构：

[1] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China

[2] Nantong Tumor Hosp, Canc Inst, Nantong 226631, Peoples R China

[3] Tongji Univ, Shanghai Peoples Hosp 10, Cent Lab Med Res, Sch Med, 36 Yunxin Rd, Shanghai 200072, Peoples R China

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2021年 / 11卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Drug therapy; cancer; inhibitor; comprehensive utilization; COLORECTAL-CANCER PROGRESSION; LONG NONCODING RNA; PROMOTES CELL-PROLIFERATION; TARGETED THERAPY; STEM-CELLS; RESISTANCE; EXPRESSION; GENE; OSTEOSARCOMA; ACTIVATION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy is one of the main treatments for cancer, especially for advanced cancer patients. In the past decade, significant progress has been made with the research into the molecular mechanisms of cancer cells and the precision medicine. The treatment on cancer patients has gradually changed from cytotoxic chemotherapy to precise treatment strategy. Research into anticancer drugs has also changed from killing effects on all cells to targeting drugs for target genes. Besides, researchers have developed the understanding of the abnormal physiological function, related genomics, epigenetics, and proteomics of cancer cells with cancer genome sequencing, epigenetic research, and proteomic research. These technologies and related research have accelerated the development of related cancer drugs. In this review, we summarize the research progress of anticancer drugs, the current challenges, and future opportunities.

引用

页码：2386 / 2400

页数：15

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