Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

被引：568
|
作者：
Xavier, B. B. [1 ,2 ,3 ]
Lammens, C. [1 ,2 ,3 ]
Ruhal, R. [1 ,2 ,3 ]
Kumar-Singh, S. [1 ,3 ,4 ]
Butaye, P. [5 ,6 ,7 ]
Goossens, H. [1 ,2 ,3 ]
Malhotra-Kumar, S. [1 ,2 ,3 ]
机构：
[1] Lab Med Microbiol, Antwerp, Belgium
[2] Vaccine & Infect Dis Inst, Antwerp, Belgium
[3] Univ Antwerp, Antwerp, Belgium
[4] Mol Pathol Grp, Cell Biol & Histol, Antwerp, Belgium
[5] Univ Ghent, Fac Vet Med, Ghent, Belgium
[6] CODA CERVA, Brussels, Belgium
[7] Ross Univ, Sch Vet Med, Basseterre, St Kitts & Nevi
来源：
EUROSURVEILLANCE | 2016年 / 21卷 / 27期
关键词：
PHOSPHOETHANOLAMINE TRANSFERASE; BLA(CTX-M); SERVER;
D O I：
10.2807/1560-7917.ES.2016.21.27.30280
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.
引用
收藏
页码：8 / 13
页数：6
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