Plasmid-mediated colistin-resistance genes: mcr

被引：17
|
作者：
Liu, Jian-Hua [1 ,2 ]
Liu, Yi-Yun [1 ,2 ]
Shen, Ying-Bo [3 ]
Yang, Jun [1 ,2 ]
Walsh, Timothy R. [4 ]
Wang, Yang [3 ]
Shen, Jianzhong [3 ]
机构：
[1] South China Agr Univ, Coll Vet Med, State Key Lab Anim Dis Control & Prevent, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China
[2] Minist Agr & Rural Affairs, Guangdong Prov Key Lab Vet Pharmaceut Dev & Safety, Key Lab Zoonosis, Guangzhou 510642, Peoples R China
[3] China Agr Univ, Coll Vet Med, Natl Key Lab Vet Publ Hlth & Safety, Beijing 100193, Peoples R China
[4] Univ Oxford, Dept Biol, Oxford, England
来源：
TRENDS IN MICROBIOLOGY | 2024年 / 32卷 / 04期
基金：
中国国家自然科学基金;
关键词：
MCR-1-POSITIVE ESCHERICHIA-COLI; PHOSPHOETHANOLAMINE TRANSFERASE; PREVALENCE; ANIMALS; CHINA; IDENTIFICATION; DYNAMICS; ORIGINS;
D O I：
10.1016/j.tim.2023.10.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Colistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles, origin of mcr, and new treatment strategies against MCR-producing pathogens have been extensively studied. Here we review the prevalence, structure and function of mcr, the fitness cost and persistence of mcr-carrying plasmids, the impact of MCR on host immune response, as well as the control strategies to combat mcrmediated colistin resistance.
引用
收藏
页码：365 / 378
页数：14
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