The effects of antidepressants in parkinson's disease: A meta-analysis

被引：20
|
作者：
Frisina, Pasquale G. [1 ,2 ]
Tenenbaum, Harriet R. [3 ]
Borod, Joan C. [4 ,5 ]
机构：
[1] Jewish Home & Hosp, Dept Med Res, Leir Parkinsons Dis Program, Lifecar Syst, New York, NY 10025 USA
[2] Mt Sinai Sch Med, Dept Geriatr & Adult Dev, New York, NY USA
[3] Kingston Univ, Dept Psychol, Kingston upon Thames KT1 2EE, Surrey, England
[4] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA
[5] Grad Ctr City Univ New York, Flushing, NY 11367 USA
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2008年 / 118卷 / 05期
关键词：
depression; meta-analysis; Parkinson's disease; treatment;
D O I：
10.1080/00207450701239418
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study explored the therapeutic effect of antidepressants in Parkinson's disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin reuptake inhibitors (SSRIs), Qb(1) = 8.87, p < .01, and the mono-amine-oxidase inhibitor, selegiline, Qb(1) = 7.90, p < .01. Whereas TCAs produced a significant side effect profile (odds ratio = 3.07), adverse events were negligible with SSRIs (odds ratio = 1.83) and selegeline (odds ratio = 1.63). Antidepressants can be beneficial for patients with PD. However, the choice of antidepressants needs to take depressive symptomatologies into account while monitoring side effects.
引用
收藏
页码：667 / 682
页数：16
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