Targeting Skin: Vitiligo and Autoimmunity

被引：9
|
作者：
Bowcock, Anne M. [1 ,2 ]
Fernandez-Vina, Marcelo [3 ]
机构：
[1] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Med, Div Dermatol, St Louis, MO 63110 USA
[3] Stanford Univ, Dept Pathol, Palo Alto, CA 94304 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2012年 / 132卷 / 01期
关键词：
GENERALIZED VITILIGO; SUSCEPTIBILITY LOCI; ASSOCIATION; MHC; PATHOGENESIS; POPULATION;
D O I：
10.1038/jid.2011.353
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
In this issue, Singh and co-workers describe the results of classical typing of human leukocyte antigen (HLA) alleles in 1,404 vitiligo patients and 902 unaffected controls from North India and follow-up HLA typing in 355 cases and 441 controls from Gujarat. The increased frequency of DRB1*07:01 in North Indian and Gujarat populations with generalized and localized vitiligo and in several vitiligo populations studied previously suggests that it contributes to autoimmunity and destruction of melanocytes.
引用
收藏
页码：13 / 15
页数：3
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