Targeting Skin: Vitiligo and Autoimmunity

被引：9

作者：

Bowcock, Anne M. ^{[1
,2
]}

Fernandez-Vina, Marcelo ^{[3
]}

机构：

[1] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, Div Dermatol, St Louis, MO 63110 USA

[3] Stanford Univ, Dept Pathol, Palo Alto, CA 94304 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2012年 / 132卷 / 01期

关键词：

GENERALIZED VITILIGO; SUSCEPTIBILITY LOCI; ASSOCIATION; MHC; PATHOGENESIS; POPULATION;

D O I：

10.1038/jid.2011.353

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In this issue, Singh and co-workers describe the results of classical typing of human leukocyte antigen (HLA) alleles in 1,404 vitiligo patients and 902 unaffected controls from North India and follow-up HLA typing in 355 cases and 441 controls from Gujarat. The increased frequency of DRB1*07:01 in North Indian and Gujarat populations with generalized and localized vitiligo and in several vitiligo populations studied previously suggests that it contributes to autoimmunity and destruction of melanocytes.

引用

页码：13 / 15

页数：3

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