New Tungsten Cluster Based Contrast Agents for X-ray Computed Tomography

被引：17

作者：

Suelzle, Detlev ^{[1
]}

Bauser, Marcus ^{[1
]}

Frenzel, Thomas ^{[1
]}

Jost, Gregor ^{[1
]}

Pietsch, Hubertus ^{[1
]}

Schaefer, Martina ^{[1
]}

Berger, Markus ^{[1
]}

Hassfeld, Jorma ^{[2
]}

Schmitt-Willich, Heribert ^{[3
]}

机构：

[1] Bayer Pharma AG, Global Drug Discovery, D-13342 Berlin, Germany

[2] Bayer Pharma AG, Global Chem Dev, D-42096 Wuppertal, Germany

[3] Piramal Imaging GmbH, D-13353 Berlin, Germany

来源：

JOURNAL OF CLUSTER SCIENCE | 2015年 / 26卷 / 01期

关键词：

Tungsten; X-ray contrast agent; Regio isomers; W3O2; complexes; Ligand design; EXCHANGE; MO;

D O I：

10.1007/s10876-014-0786-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In recognition of the seminal contributions of F. A. Cotton and A. Bino to the field of aqueous chemistry of organometallic, trinuclear cluster compounds of tungsten, we describe their modifications and use as contrast agents for X-ray computed tomography. To enable their fundamental work for an advantageous diagnostic application in medicine a new generation of polydentate W3O2 complexes with improved hydrolytical stability has been synthesized and characterized. The applicability as new metal based contrast agent has been demonstrated in a computed tomography angiography animal study with increased signal intensity. Especially the bis tridentate W3O2 complexes with their reduced stereochemical complexity represent a promising new class in the field of X-ray contrast agents.

引用

页码：111 / 118

页数：8

共 50 条

[41] NEW SCINTILLATORS FOR X-RAY COMPUTED-TOMOGRAPHY
GRABMAIER, BC
ROSSNER, W
NUCLEAR TRACKS AND RADIATION MEASUREMENTS, 1993, 21 (01): : 43 - 45
[42] New Developments and Applications of X-Ray Computed Tomography
Zhu, Lei
CURRENT MEDICAL IMAGING REVIEWS, 2010, 6 (02) : 60 - 60
[43] A new scanning technique for X-ray computed tomography
Nukaga, Jun
Kitazawa, So
Kamimura, Hiroshi
NDT & E INTERNATIONAL, 2008, 41 (07) : 564 - 569
[44] Contrast Improvement of Biodegradable Stents for X-ray Computed Tomography Visualization
Winters, James
Bennett, James
Guelcher, Manfred
Mathur, Anthony
Martin, John
Fahmy, Tarek
Sinusas, Albert
CIRCULATION, 2014, 130
[45] Developments in X-Ray Contrast Media and the Potential Impact on Computed Tomography
Schoeckel, Laura
Jost, Gregor
Seidensticker, Peter
Lengsfeld, Philipp
Palkowitsch, Petra
Pietsch, Hubertus
INVESTIGATIVE RADIOLOGY, 2020, 55 (09) : 592 - 597
[46] Recent observations with phase-contrast X-ray computed tomography
Momose, A
Takeda, T
Itai, Y
Tu, JH
Hirano, K
DEVELOPMENTS IN X-RAY TOMOGRAPHY II, 1999, 3772 : 188 - 195
[47] Helical differential X-ray phase-contrast computed tomography
Fu, Jian
Willner, Marian
Chen, Liyuan
Tan, Renbo
Achterhold, Klaus
Bech, Martin
Herzen, Julia
Kunka, Danays
Mohr, Juergen
Pfeiffer, Franz
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2014, 30 (03): : 374 - 379
[48] Phase-contrast X-ray computed tomography for biological imaging
Momose, A
Takeda, T
Itai, Y
DEVELOPMENTS IN X-RAY TOMOGRAPHY, 1997, 3149 : 120 - 129
[49] Beam hardening in x-ray differential phase contrast computed tomography
Bevins, Nicholas
Zambelli, Joseph
Li, Ke
Qi, Zhihua
Chen, Guang-Hong
MEDICAL IMAGING 2011: PHYSICS OF MEDICAL IMAGING, 2011, 7961
[50] VIDEO BASED X-RAY COMPUTED-TOMOGRAPHY
QU, LZ
NALCIOGLU, O
ROECK, WW
RABBANI, B
COLMAN, M
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1986, 33 (01) : 527 - 530

← 1 2 3 4 5 →