New Tungsten Cluster Based Contrast Agents for X-ray Computed Tomography

被引：17
|
作者：
Suelzle, Detlev [1 ]
Bauser, Marcus [1 ]
Frenzel, Thomas [1 ]
Jost, Gregor [1 ]
Pietsch, Hubertus [1 ]
Schaefer, Martina [1 ]
Berger, Markus [1 ]
Hassfeld, Jorma [2 ]
Schmitt-Willich, Heribert [3 ]
机构：
[1] Bayer Pharma AG, Global Drug Discovery, D-13342 Berlin, Germany
[2] Bayer Pharma AG, Global Chem Dev, D-42096 Wuppertal, Germany
[3] Piramal Imaging GmbH, D-13353 Berlin, Germany
来源：
JOURNAL OF CLUSTER SCIENCE | 2015年 / 26卷 / 01期
关键词：
Tungsten; X-ray contrast agent; Regio isomers; W3O2; complexes; Ligand design; EXCHANGE; MO;
D O I：
10.1007/s10876-014-0786-1
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In recognition of the seminal contributions of F. A. Cotton and A. Bino to the field of aqueous chemistry of organometallic, trinuclear cluster compounds of tungsten, we describe their modifications and use as contrast agents for X-ray computed tomography. To enable their fundamental work for an advantageous diagnostic application in medicine a new generation of polydentate W3O2 complexes with improved hydrolytical stability has been synthesized and characterized. The applicability as new metal based contrast agent has been demonstrated in a computed tomography angiography animal study with increased signal intensity. Especially the bis tridentate W3O2 complexes with their reduced stereochemical complexity represent a promising new class in the field of X-ray contrast agents.
引用
收藏
页码：111 / 118
页数：8
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