MoS2 quantum dots as fluorescent probe for methotrexate detection

被引：5

作者：

Yang, Like ^{[1
]}

Ge, Jia ^{[1
]}

Ma, Demiao ^{[1
]}

Tang, Jinlu ^{[1
]}

Wang, Hongqi ^{[2
]}

Li, Zhaohui ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Sch Basic Med Sci, Zhengzhou 450001, Peoples R China

[2] Henan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Zhengzhou, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2022年 / 279卷

基金：

中国国家自然科学基金;

关键词：

Methotrexate; MoS(2 )quantum dots; Inner filter effect; Fluorescence; Biosensor; HIGH-DOSE METHOTREXATE; FACILE SYNTHESIS; ELECTROCHEMICAL SENSOR; PHOTOLUMINESCENCE; 2,4,6-TRINITROPHENOL; QUANTIFICATION; URINE; HPLC;

D O I：

10.1016/j.saa.2022.121443

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Herein, we developed a unique fluorescence biosensor for methotrexate assay based on MoS(2 )quantum dots, which were synthesized in one step using sodium molybdate and cysteine as raw materials. The fluorescence of MoS(2 )QDs could be quenched when encountered with methotrexate, which was attributed to the inner filter effect (IFE). Furthermore, this present IFE-based method showed the linearity between the MoS(2 )QDs fluorescence intensity and the methotrexate concentration in the range of 0.05-1 mu M with the LOD of 42 nM. The practical applicability of this strategy was successfully demonstrated by detecting methotrexate in real samples. Results indicated that the proposed method could be a promising sensing platform for methotrexate analysis.

引用

页数：6

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