Lessons from bacterial homolog of tubulin, FtsZ for microtubule dynamics

被引:20
|
作者
Battaje, Rachana Rao [1 ]
Panda, Dulal [1 ]
机构
[1] Indian Inst Technol, Dept Biosci & Bioengn, Bombay, Maharashtra, India
关键词
FtsZ assembly; microtubules; cell division; anticancer drugs; antibacterial drugs; CELL-DIVISION PROTEIN; ALPHA-BETA-TUBULIN; COMBRETASTATIN A4 PHOSPHATE; ESCHERICHIA-COLI FTSZ; GUANOSINE-TRIPHOSPHATASE-ACTIVITY; GTP-DEPENDENT POLYMERIZATION; PRIMITIVE RED ALGA; TARGETING FTSZ; BINDING-SITE; IN-VITRO;
D O I
10.1530/ERC-17-0118
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
FtsZ, a homolog of tubulin, is found in almost all bacteria and archaea where it has a primary role in cytokinesis. Evidence for structural homology between FtsZ and tubulin came from their crystal structures and identification of the GTP box. Tubulin and FtsZ constitute a distinct family of GTPases and show striking similarities in many of their polymerization properties. The differences between them, more so, the complexities of microtubule dynamic behavior in comparison to that of FtsZ, indicate that the evolution to tubulin is attributable to the incorporation of the complex functionalities in higher organisms. FtsZ and microtubules function as polymers in cell division but their roles differ in the division process. The structural and partial functional homology has made the study of their dynamic properties more interesting. In this review, we focus on the application of the information derived from studies on FtsZ dynamics to study microtubule dynamics and vice versa. The structural and functional aspects that led to the establishment of the homology between the two proteins are explained to emphasize the network of FtsZ and microtubule studies and how they are connected.
引用
收藏
页码:T1 / T21
页数:21
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