Synthesis and anticancer activity of 2,3,4-trimethoxyacetophenoxime ester containing benzothiazole moiety

被引：20
|
作者：
Song, BA [1 ]
Liu, XH [1 ]
Yang, S [1 ]
Hu, DY [1 ]
Jin, LH [1 ]
Zhang, H [1 ]
机构：
[1] Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2005年 / 23卷 / 09期
关键词：
oxime ester; synthesis; anticancer activity;
D O I：
10.1002/cjoc.200591236
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2,3,4-trimethoxyacetophenoxime esters containing benzothiazole moiety were synthesized by the reaction of oxime with acyl chloride in alkaline medium. Their structures were established by elemental analysis, IR, and H-1 NMR spectra. The bioassay tests showed that these tide compounds exhibit moderate anticancer activity in vitro by MTT method and compounds 6c and 6d could inhibit ERK phosphorylation in NIH 3T3 cell induced by PDGF.
引用
收藏
页码：1236 / 1240
页数：5
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