Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the mechanism of downbeat nystagmus

被引：21

作者：

Glasauer, S ^{[1
]}

Strupp, M ^{[1
]}

Kalla, R ^{[1
]}

Büttner, U ^{[1
]}

Brandt, T ^{[1
]}

机构：

[1] Univ Munich, Dept Neurol, Ctr Sensorimotor Res, D-81377 Munich, Germany

来源：

CLINICAL AND BASIC OCULOMOTOR RESEARCH: IN HONOR OF DAVID S. ZEE | 2005年 / 1039卷

关键词：

patient; cerebellum; potassium channel blocker;

D O I：

10.1196/annals.1325.060

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The potassium channel blocker 4-aminopyridine (4-AP) restored vertical smooth pursuit and gaze holding in light in one patient with upbeat (UBN) and in one with downbeat nystagmus (DBN). Without a visible target, however, 4-AP had no effect on UBN, but DBN vanished. We hypothesize that this difference in the effects of 4-AP, which is known to increase the excitability of cerebellar Purkinje cells, can be attributed to the different lesion sites involved in UBN and DBN.

引用

页码：528 / 531

页数：4

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