Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the mechanism of downbeat nystagmus

被引：21
|
作者：
Glasauer, S [1 ]
Strupp, M [1 ]
Kalla, R [1 ]
Büttner, U [1 ]
Brandt, T [1 ]
机构：
[1] Univ Munich, Dept Neurol, Ctr Sensorimotor Res, D-81377 Munich, Germany
来源：
CLINICAL AND BASIC OCULOMOTOR RESEARCH: IN HONOR OF DAVID S. ZEE | 2005年 / 1039卷
关键词：
patient; cerebellum; potassium channel blocker;
D O I：
10.1196/annals.1325.060
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The potassium channel blocker 4-aminopyridine (4-AP) restored vertical smooth pursuit and gaze holding in light in one patient with upbeat (UBN) and in one with downbeat nystagmus (DBN). Without a visible target, however, 4-AP had no effect on UBN, but DBN vanished. We hypothesize that this difference in the effects of 4-AP, which is known to increase the excitability of cerebellar Purkinje cells, can be attributed to the different lesion sites involved in UBN and DBN.
引用
收藏
页码：528 / 531
页数：4
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