Diet compounds, glycemic index and obesity-related cardiac effects

被引:29
|
作者
Diniz, Yeda S. [1 ]
Burneiko, Regina M. [1 ]
Seiva, Fabio R. F. [2 ]
Almeida, Flavia Q. A. [3 ]
Galhardi, Cristiano Machado [2 ]
Novelli Filho, Jose Luiz V. B. [4 ]
Mani, Fernanda [1 ]
Novelli, Ethel L. B. [1 ]
机构
[1] UNESP, Sao Paulo State Univ, Dept Chem & Biochem, Inst Biol Sci, BR-18618000 Botucatu, SP, Brazil
[2] UNESP, Sao Paulo State Univ, Sch Med, Dept Clin & Cardiol,Post Grad Course, Botucatu, SP, Brazil
[3] UNESP, Sao Paulo State Univ, Dept Educ, Inst Biol Sci,Nutr Area, Botucatu, SP, Brazil
[4] UNESP, Sao Paulo State Univ, Sch Med, Botucatu, SP, Brazil
关键词
obesity; diet compounds; glycemic index; heart; oxidative stress; metabolism; CORONARY-HEART-DISEASE; OXIDATIVE STRESS; SERUM-LIPIDS; FATTY-ACIDS; OLIVE OIL; RESTRICTION; SUPPLEMENTATION; HYPERGLYCEMIA; DYSLIPIDEMIA; GLUTATHIONE;
D O I
10.1016/j.ijcard.2006.12.025
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Diet compounds may influence obesity-related cardiac oxidative stress and metabolic sifting. Carbohydrate-rich diet may be disadvantageous from fat-rich diet to cardiac tissue and glycemic index rather than lipid profile may predict the obesity-related cardiac effects. Materials and methods: Male Wistar rats were divided into three groups (n=8/group): (C) receiving standard chow (3.0 kcal/g); (CRD) receiving carbohydrate-rich diet (4.0 kcal/g), and (FRD) receiving fat-rich diet (4.0 kcal/g). Rats were sacrificed after the oral glucose tolerance test (OGTT) at 60 days of dietary treatments. Lipid profile and oxidative stress parameters were determined in serum. Myocardial samples were used to determine oxidative stress, metabolic enzymes, glycogen and triacylglycerol. Results: FRD rats showed higher final body weight and body mass index than CRD and C. Serum cholesterol and low-density lipoprotein were higher in FRD than in CRD, while triacylglycerol and oxidized low-density lipoprotein cholesterol were higher in CRD than in FRD. CRD rats had the highest myocardial lipid hydroperoxide and diminished superoxide dismutase and catalase activities. Myocardial glycogen was lower and triacylglycerol was higher in CRD than in C and FRD rats. Although FRD rats had depressed myocardial-reducing power, no significant changes were observed in myocardial energy metabolism. Myocardial beta-hydroxyacyl coenzyme-A dehydrogenase and citrate synthase, as well as the enhanced lactate debydrogenase/citrate synthase ratio indicated that fatty acid degradation was decreased in CRD rats. Glycemic index was positively correlated with obesity-related cardiac effects. Conclusions: Isoenergetic carbohydrate-rich and fat-rich diets induced different degree of obesity and differently affected lipid profile. Carbohydrate-rich diet was deleterious relative to fat-rich diet in the heart enhancing lipoperoxidation and shifting the metabolic pathway for energy production. Glycemic index rather than dyslipidemic profile may predict the obesity effects on cardiac tissue. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:92 / 99
页数:8
相关论文
共 50 条
  • [31] Role of low-glycemic index diet in management of childhood obesity
    Kong, A. P. S.
    Chan, R. S. M.
    Nelson, E. A. S.
    Chan, J. C. N.
    OBESITY REVIEWS, 2011, 12 (07) : 492 - 498
  • [32] Hypercaloric Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Experimental Models
    Pinheiro-Castro, Natalia
    Aparecida Ribeiro Silva, Livia Beatriz
    Novaes, Gabriela Machado
    Ong, Thomas Prates
    REVIEWS ON BIOMARKER STUDIES OF METABOLIC AND METABOLISM-RELATED DISORDERS, 2019, 1134 : 149 - 161
  • [33] The role of a low-glycemic-index diet in the management of obesity - Reply
    Sloth, B
    Krog-Mikkelsen, I
    Flint, A
    Tetens, I
    Astrup, A
    Raben, A
    Elmstahl, H
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 81 (04): : 941 - 941
  • [34] Clinical characteristics and treatment compounds of obesity-related kidney injury
    Mao, Tuo-Hua
    Huang, Han-Qi
    Zhang, Chuan-Hai
    WORLD JOURNAL OF DIABETES, 2024, 15 (06)
  • [35] Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease
    Limpitikul, Worawan B.
    Das, Saumya
    JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, 2023, 10 (08)
  • [36] Obesity-Related Hypertension
    Re, Richard N.
    OCHSNER JOURNAL, 2009, 9 (03): : 133 - 136
  • [37] Obesity-related glomerulopathy
    Tran, HA
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (12): : 6358 - 6358
  • [38] Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation
    Huang C.-J.
    McAllister M.J.
    Slusher A.L.
    Webb H.E.
    Mock J.T.
    Acevedo E.O.
    Sports Medicine - Open, 2015, 1 (1)
  • [39] Obesity-related alterations
    不详
    International Journal of Obesity, 1999, 23 (Suppl 5) : S127 - S136
  • [40] Obesity-related hypertension
    Adamczak, Marcin
    Gojowy, Damian
    Wiecek, Andrzej
    ARTERIAL HYPERTENSION, 2014, 18 (04): : 224 - 236