Activation of platelet-derived growth factor (PDGF) receptor dephosphorylation in intact Swiss 3T3 cells by elevators of intracellular Ca2+ and cAMP

被引：6
|
作者：
Bohmer, FD [1 ]
Bohmer, SA [1 ]
机构：
[1] UNIV JENA,FAC MED,INST BIOCHEM 2,D-07743 JENA,GERMANY
来源：
FEBS LETTERS | 1996年 / 391卷 / 1-2期
关键词：
platelet-derived growth factor receptor; receptor dephosphorylation; protein tyrosine phosphatase; fibroblast (Swiss 3T3);
D O I：
10.1016/0014-5793(96)00740-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the modulation of platelet-derived growth factor (PDGF) receptor dephosphorylation in Swiss 3T3 cells using a novel assay permitting monitoring of receptor dephosphorylation in intact cells, PDGF treatment of the cells reduced the receptor dephosphorylation rate to 41%, the elevators of intracellular Ca2+, A23187 and thapsigargin increasing it to 227 and 138%, respectively, The cAMP elevators forskolin and isobutylmethylxanthine also accelerated PDGF receptor dephosphorylation, The involvement of Ca2+- and cAMP-dependent protein kinases in the regulation of PDGF receptor dephosphorylation is suggested.
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页码：219 / 222
页数：4
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