Cardiovascular diseases and genome-wide association studies

被引：18

作者：

Ndiaye, Ndeye Coumba ^{[1
]}

Nehzad, Mohsen Azimi ^{[1
]}

El Shamieh, Said ^{[1
]}

Stathopoulou, Maria G. ^{[1
]}

Visvikis-Siest, Sophie ^{[1
]}

机构：

[1] Univ Henri Poincare, Fac Pharm, Cardiovasc Genet Res Unit EA4373, F-54000 Nancy, France

来源：

CLINICA CHIMICA ACTA | 2011年 / 412卷 / 19-20期

关键词：

Genome-Wide Association Studies; Cardiovascular diseases; Cardiovascular-related quantitative traits; Gene-gene interactions; Gene-environment interactions; CORONARY-ARTERY-DISEASE; SINGLE NUCLEOTIDE POLYMORPHISMS; BLOOD-PRESSURE; GENETIC-DETERMINANTS; HEART-DISEASE; RISK-FACTORS; ESSENTIAL-HYPERTENSION; MYOCARDIAL-INFARCTION; MISSING HERITABILITY; SUSCEPTIBILITY LOCUS;

D O I：

10.1016/j.cca.2011.05.035

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Genome-Wide Association Studies (GWAS) on cardiovascular diseases and related quantitative traits revealed numerous genetic variants, which however have been partially replicated, probably due to the heterogeneity of the clinical phenotypes and the populations studied. Even if novel biological pathways have been identified through these studies, there is still a long way until the validation of causal variants and their use in clinical practice as factors for prevention, risk assessment and as targets for the development of new medications. GWAS methodologies should, in the following years, integrate gene-gene and gene-environment interaction analyses in a global research strategy and also involve subsequent transcriptomic and proteomic investigations. The GWAS era is very promising but it is just at the beginning. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1697 / 1701

页数：5

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