Discrepant expressive language lateralization in children and adolescents with epilepsy

被引：2

作者：

Pasichnik, Alisa ^{[1
,2
,3
]}

Tsuboyama, Melissa ^{[1
,2
]}

Jannati, Ali ^{[1
,2
,3
,4
,5
]}

Vega, Clemente ^{[1
,2
,6
]}

Kaye, Harper L. ^{[1
,2
,7
]}

Damar, Ugur ^{[1
,2
,3
]}

Bolton, Jeffrey ^{[1
,2
]}

Stone, Scellig S. D. ^{[8
]}

Madsen, Joseph R. ^{[8
]}

Suarez, Ralph O. ^{[9
]}

Rotenberg, Alexander ^{[1
,2
,3
,4
,5
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, Neuromodulat Program, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, Div Epilepsy & Clin Neurophysiol, Boston, MA 02115 USA

[3] Harvard Med Sch, FM Kirby Neurobiol Ctr, Boston Childrens Hosp, Boston, MA 02115 USA

[4] Harvard Med Sch, Berenson Allen Ctr Noninvas Brain Stimulat, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA

[5] Harvard Med Sch, Div Cognit Neurol, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA

[6] Harvard Med Sch, Neuropsychol Ctr, Boston Childrens Hosp, Dept Psychiat, Boston, MA 02115 USA

[7] Boston Univ, Sch Med, Behav Neurosci Program, Boston, MA 02118 USA

[8] Harvard Med Sch, Boston Childrens Hosp, Dept Neurosurg, Boston, MA 02115 USA

[9] Harvard Med Sch, Boston Childrens Hosp, Dept Radiol, Boston, MA 02115 USA

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2022年 / 9卷 / 09期

关键词：

TRANSCRANIAL MAGNETIC STIMULATION; CORTICAL STIMULATION; FUNCTIONAL MRI; DOMINANCE; SURGERY; WADA; FMRI;

D O I：

10.1002/acn3.51594

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuronavigated transcranial magnetic stimulation (nTMS) has emerged as a presurgical language mapping tool distinct from the widely used functional magnetic resonance imaging (fMRI). We report fMRI and nTMS language-mapping results in 19 pediatric-epilepsy patients and compare those to definitive testing by electrical cortical stimulation, Wada test, and/or neuropsychological testing. Most discordant results occurred when fMRI found right-hemispheric language. In those cases, when nTMS showed left-hemispheric or bilateral language representation, left-hemispheric language was confirmed by definitive testing. Therefore, we propose nTMS should be considered for pediatric presurgical language-mapping when fMRI shows right-hemispheric language, with nTMS results superseding fMRI results in those scenarios.

引用

页码：1459 / 1464

页数：6

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