Use of population isolates for mapping complex traits

被引：293
|
作者：
Peltonen, L
Palotie, A
Lange, K
机构：
[1] Univ Helsinki, Dept Med Genet, FIN-00014 Helsinki, Finland
[2] Natl Inst Publ Hlth, Helsinki, Finland
[3] Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90095 USA
来源：
NATURE REVIEWS GENETICS | 2000年 / 1卷 / 03期
关键词：
D O I：
10.1038/35042049
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Geneticists have repeatedly turned to population isolates for mapping and cloning Mendelian disease genes. Population' isolates possess many advantages in this regard. Foremost among these is the tendency for affected individuals to share ancestral haplotypes derived from a handful of founders. These haplotype signatures have guided scientists in the fine mapping of scores of rare disease genes. The past successes with Mendelian disorders using population isolates have prompted unprecedented interest among medical researchers in both the public and private sectors. Despite the obvious genetic and environmental complications, geneticists have targeted several population isolates for mapping genes for complex diseases.
引用
收藏
页码：182 / 190
页数：9
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