Solubility and Hansen Solubility Parameter of Nα-Carbobenzyloxy-L-Arginine in Twelve Individual Solvents from 283.15 to 323.15 K

The solubility data of N-alpha-carbobenzyloxy-L-arginine in 12 individual solvents (water, dimethylformamide, methanol, ethanol, isopropanol, 1-butanol, acetone, acetonitrile, dichloromethane, ethyl acetate, and 2-butanone) were determined by the static gravimetric method in the temperature range from 283.15 to 323.15 K. The results show that all the solubility increases with the increase in temperature. In the selected solvent systems, three different polymorphs named the alpha-form, beta-form, and gamma-form were found. In addition, the Hansen solubility parameters (HSPs) were used to analyze the dissolution behavior. According to the solubility data analysis results, the dissolution behavior was affected by the HSPs, polarity, hydrogen bond, and cohesive energy density. The Apelblat model and the Yaws model were used to correlate the solubility data, and their fitting effect was evaluated by the Akaike information criterion method.