Bulleyaconitine A inhibits the lung inflammation and airway remodeling through restoring Th1/Th2 balance in asthmatic model mice

被引：11

作者：

Liu, Liping ^{[1
]}

Wang, Shuyun ^{[1
]}

Xing, Haiyan ^{[1
]}

Sun, Yuemei ^{[1
]}

Ding, Juan ^{[1
]}

He, Ning ^{[1
]}

机构：

[1] Yantai Yuhuangding Hosp, Dept Allergy, Yantai, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2020年 / 84卷 / 07期

关键词：

Asthma; Bulleyaconitine A; inflammation; airway remodeling; Th1; Th2; cytokines; T-LYMPHOCYTES; CYTOKINES; PATHOGENESIS;

D O I：

10.1080/09168451.2020.1752140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current study aimed to study the effects of Bulleyaconitine A (BLA) on asthma. Asthmatic mice model was established by ovalbumin (OVA) stimulation, and the model mice were treated by BLA. After BLA treatment, the changes in lung and airway resistances, total and differential leukocytes in the bronchoalveolar lavage fluid (BALF) were detected, and the changes in lung inflammation and airway remodeling were observed. Moreover, the secretion of IgE, Th1/Th2-type and IL-17A cytokines in BALF and serum of the asthmatic mice were determined. The resuts showed that BLA attenuated OVA-induced lung and airway resistances, inhibited the inflammatory cell recruitment in BALF and the inflammation and airway remodeling of the asthmatic mice. In addition, BLA suppressed the secretion of IgE, Th2-type cytokines, and IL-17A, but enhanced secretions of Th1-type cytokines in BALF and serum. The current study discovered that BLA inhibited the lung inflammation and airway remodeling via restoring the Th1/Th2 balance in asthmatic mice.

引用

页码：1409 / 1417

页数：9

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