The microenvironment of the tumour-host interface

被引：1894
|
作者：
Liotta, LA [1 ]
Kohn, EC [1 ]
机构：
[1] NCI, Pathol Lab, Ctr Canc Res, Bethesda, MD 20892 USA
来源：
NATURE | 2001年 / 411卷 / 6835期
关键词：
D O I：
10.1038/35077241
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Throughout the entire process of cancer aetiology, progression and metastasis, the microenvironment of the local host tissue can be an active participant. Invasion occurs within a tumour-host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate migration, and promote proliferation and survival. A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.
引用
收藏
页码：375 / 379
页数：5
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