Cloning and sequencing of a human cDNA encoding endothelial P2Y(1) purinoceptor

被引：83
|
作者：
Leon, C [1 ]
Vial, C [1 ]
Cazenave, JP [1 ]
Gachet, C [1 ]
机构：
[1] ETABLISSEMENT TRANSFUS SANGUINE STRASBOURG,INSERM,U311,F-67065 STRASBOURG,FRANCE
来源：
GENE | 1996年 / 171卷 / 02期
关键词：
ATP receptor; G-protein-coupled receptor; nucleotide; endothelial cells;
D O I：
10.1016/0378-1119(96)00027-3
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We have cloned and sequenced a 3055-bp human placenta cDNA encoding a P-2 purinoceptor. An identical receptor has also been found in human saphenous vein endothelial cells. Comparison of the deduced amino acid (aa) sequence to those of previously described P2Y(1) purinoceptors revealed greater than 95% aa identity with the rat and mouse counterparts, and 83% with the chick P2Y(1) purinoceptor. Northern blot experiments revealed two mRNAs of 7.5 and 4.6 kb whose expression varies according to the tissue examined.
引用
收藏
页码：295 / 297
页数：3
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