Photochemical synthesis of [1,4]-benzodiazepines and pyrrolo-[1,4]-benzodiazepines

被引：0

作者：

Kramer, W ^{[1
]}

Griesbeck, AG ^{[1
]}

机构：

[1] Univ Cologne, Inst Organ Chem, D-50939 Cologne, Germany

来源：

JOURNAL OF INFORMATION RECORDING | 2000年 / 25卷 / 1-2期

关键词：

decarboxylation; photoinduced electron transfer; 1,4]-benzodiazepines; pyrrolo-[1,4]-benzodiazepines;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Coupling of anthranilic acid with phthalic anhydride and a series of alpha -amino acids gave photoactive substrates which were cyclized by irradiation in water/acetone mixtures (1:1) in the presence of potassium carbonate. The photodecarboxylation and subsequent radical combination resulted in [1,4]-benzodiazepines und pyrrolo-[1,4]-benzodiazepines in moderate yields and high diastereoselectivities. For enantiomerically pure starting materials it was shown that the cyclization step occures with high enantioselectivity.

引用

页码：235 / 238

页数：4

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