Synthesis of cyclic and acyclic Nα-methyl-Nω-alkyl-L-arginine analogues

被引：6
|
作者：
Kokko, KP
Hooper, HB
Dix, TA
机构：
[1] Med Univ S Carolina, Dept Pharmaceut Sci, Charleston, SC 29425 USA
[2] Argolyn Biosci Inc, Mt Pleasant, SC 29464 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期
关键词：
amino acids; arginine; peptides;
D O I：
10.1016/j.tetlet.2004.01.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of Nalpha-methyl-alkyl-L-arginine (Arg) analogues have been synthesized from inexpensive, commercially available starting rnaterials. These analogues, once incorporated into pharmaceutically relevant peptides, are expected to increase binding affinity, receptor selectivity, lipophificity, and stability Lis demonstrated With analogues of similar design and Structure. (C) 2001 Published by Elsevier Ltd.
引用
收藏
页码：2151 / 2153
页数：3
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