Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin

被引：36
|
作者：
Sakya, SM [1 ]
Suarez-Contreras, M [1 ]
Dirlam, JP [1 ]
O'Connell, TN [1 ]
Hayashi, SF [1 ]
Santoro, SL [1 ]
Kamicker, BJ [1 ]
George, DM [1 ]
Ziegler, CB [1 ]
机构：
[1] Pfizer Inc, Pfizer Global Res & Dev, Vet Med Pharmaceut Discovery, Groton, CT 06340 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 20期
关键词：
D O I：
10.1016/S0960-894X(01)00567-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycin against Staphylococcus aureus and comparable activity against Pasteurella multocida. Several semisynthetically modified analogues of thiolactomycin showed no improvement in activity over thiolactomycin. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：2751 / 2754
页数：4
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