Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin

被引：36
|
作者：
Sakya, SM [1 ]
Suarez-Contreras, M [1 ]
Dirlam, JP [1 ]
O'Connell, TN [1 ]
Hayashi, SF [1 ]
Santoro, SL [1 ]
Kamicker, BJ [1 ]
George, DM [1 ]
Ziegler, CB [1 ]
机构：
[1] Pfizer Inc, Pfizer Global Res & Dev, Vet Med Pharmaceut Discovery, Groton, CT 06340 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 20期
关键词：
D O I：
10.1016/S0960-894X(01)00567-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens. Some analogues showed improved activity over thiolactomycin against Staphylococcus aureus and comparable activity against Pasteurella multocida. Several semisynthetically modified analogues of thiolactomycin showed no improvement in activity over thiolactomycin. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2751 / 2754
页数：4
相关论文
共 50 条
  • [1] Synthesis of tacrine analogues and their structure-activity relationships
    Proctor, GR
    Harvey, AL
    [J]. CURRENT MEDICINAL CHEMISTRY, 2000, 7 (03) : 295 - 302
  • [2] Butitaxel analogues: Synthesis and structure-activity relationships
    Ali, SM
    Hoemann, MZ
    Aube, J
    Georg, GI
    Mitscher, LA
    Jayasinghe, LR
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (02) : 236 - 241
  • [3] Structure-activity relationships of fluorinated lysophosphatidic acid analogues
    Xu, Y
    Aoki, J
    Shimizu, K
    Umezu-Goto, M
    Hama, K
    Takanezawa, Y
    Yu, SX
    Mills, GB
    Arai, H
    Qian, L
    Prestwich, GD
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (09) : 3319 - 3327
  • [4] Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues
    Babu, K. Suresh
    Li, Xing-Cong
    Jacob, Melissa R.
    Zhang, Qifeng
    Khan, Shabana I.
    Ferreira, Daneel
    Clark, Alice M.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (26) : 7877 - 7886
  • [5] Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues
    Reddy, P. Prabhakar
    Lavekar, Aditya G.
    Babu, K. Suresh
    Rao, R. Ranga
    Shashidhar, J.
    Shashikiran, G.
    Rao, J. Madhusudana
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (08) : 2525 - 2528
  • [6] Synthesis and Structure-Activity Relationships of Vasicine Analogues as Bronchodilatory Agents
    Neeraj Mahindroo
    Zabeer Ahmed
    Asha Bhagat
    Kasturi Lal Bedi
    Ravi Kant Khajuria
    Vijay Kumar Kapoor
    Kanaya Lal Dhar
    [J]. Medicinal Chemistry Research, 2005, 14 : 347 - 368
  • [7] 8-aminocyclazocine analogues: Synthesis and structure-activity relationships
    Wentland, MP
    Xu, GY
    Cioffi, CL
    Ye, YC
    Duan, WH
    Cohen, DJ
    Colasurdo, AM
    Bidlack, JM
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (02) : 183 - 187
  • [8] Structure-activity relationships of ustiloxin analogues
    Joullie, Madeleine M.
    Berritt, Simon
    Hamel, Ernest
    [J]. TETRAHEDRON LETTERS, 2011, 52 (17) : 2136 - 2139
  • [9] Synthesis and structure-activity relationships of vasicine analogues as bronchodilatory agents
    Mahindroo, Neeraj
    Ahmed, Zabeer
    Bhagat, Asha
    Bedi, Kasturi Lal
    Khajuria, Ravi Kant
    Kapoor, Vijay Kumar
    Mara, Kanaya Lal
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2005, 14 (06) : 347 - 368
  • [10] Synthesis and Structure-Activity Relationships of Lansine Analogues as Antileishmanial Agents
    Pieroni, Marco
    Girmay, Sisay
    Sun, Dianqing
    Sahu, Rajnish
    Tekwani, Babu L.
    Tan, Ghee T.
    [J]. CHEMMEDCHEM, 2012, 7 (11) : 1895 - 1900
12345